EGF (Epidermal Growth Factor) is a growth factor that stimulates cell growth, proliferation, and differentiation by binding to its receptor EGFR. EGF results in cellular proliferation, differentiation, and survival.
EGF acts by binding with high affinity toepidermal growth factor receptor (EGFR) on the cell surface and stimulating the intrinsic protein-tyrosine kinase activity of the receptor. Thetyrosine kinase activity, in turn, initiates asignal transduction cascade that results in a variety of biochemical changes within the cell – a rise in intracellular calcium levels, increased glycolysis and protein synthesis, and increases in the expression of certaingenes including the gene for EGFR – that ultimately lead to DNA synthesis and cell proliferation.
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